Abstract
As trans-membrane proteins located in cytoplasm and organelle membrane, potassium (K+) channels are generally divided into four super-families: voltage-gated K+ channels (Kv), Ca2+-activated K+ channels (KCa), inwardly rectifying K+ channels (Kir) and two-pore domain K+ channels (K2P). Since dysfunctions of K+ channels would induce many diseases, various studies toward their functions in physiologic and pathologic process have been extensively launched. This review focuses on the recent advances of K+ channels in tumor progression, including the brief introduction of K+ channels, the role of K+ channels in tumor cells, the possible mechanism of action at cellular level, and the possible application of K+ channel modulators in cancer chemotherapy.
Keywords: Cancer chemotherapy, Kv, KCa, Kir, K2P, K+ channel modulators, mechanisms of action
Current Topics in Medicinal Chemistry
Title: Research Toward Potassium Channels on Tumor Progression
Volume: 9 Issue: 4
Author(s): Zheng Shen, Qian Yang and Qidong You
Affiliation:
Keywords: Cancer chemotherapy, Kv, KCa, Kir, K2P, K+ channel modulators, mechanisms of action
Abstract: As trans-membrane proteins located in cytoplasm and organelle membrane, potassium (K+) channels are generally divided into four super-families: voltage-gated K+ channels (Kv), Ca2+-activated K+ channels (KCa), inwardly rectifying K+ channels (Kir) and two-pore domain K+ channels (K2P). Since dysfunctions of K+ channels would induce many diseases, various studies toward their functions in physiologic and pathologic process have been extensively launched. This review focuses on the recent advances of K+ channels in tumor progression, including the brief introduction of K+ channels, the role of K+ channels in tumor cells, the possible mechanism of action at cellular level, and the possible application of K+ channel modulators in cancer chemotherapy.
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Cite this article as:
Shen Zheng, Yang Qian and You Qidong, Research Toward Potassium Channels on Tumor Progression, Current Topics in Medicinal Chemistry 2009; 9 (4) . https://dx.doi.org/10.2174/156802609788317874
DOI https://dx.doi.org/10.2174/156802609788317874 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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