Abstract
2,2,5,7,8-Pentamethyl-6-chromanylamine-15N was prepared by condensation of ZnCl2-catalyzed condensation of 2,3,5-trimethylphenol with isoprene, followed by conversion of the resulting chroman into the 6-nitro-derivative and further reduction to the title compound, which possesses a 2-methyl group instead of the isoprenoid side chain of tocopherols and tocopheramines. Tocopheramines and their short-chain analogues are current targets in medicinal chemistry and anti-cancer research.
Keywords: Tocopherols, tocopheramine, vitamin E, isotopic labeling, chromans
Letters in Organic Chemistry
Title: Synthesis of the α-Tocopheramine-15N Model Compound 2,2,5,7,8- Pentamethyl-6-chromanylamine-15N
Volume: 7 Issue: 4
Author(s): Stefan Bohmdorfer, Lars Gille and Thomas Rosenau
Affiliation:
Keywords: Tocopherols, tocopheramine, vitamin E, isotopic labeling, chromans
Abstract: 2,2,5,7,8-Pentamethyl-6-chromanylamine-15N was prepared by condensation of ZnCl2-catalyzed condensation of 2,3,5-trimethylphenol with isoprene, followed by conversion of the resulting chroman into the 6-nitro-derivative and further reduction to the title compound, which possesses a 2-methyl group instead of the isoprenoid side chain of tocopherols and tocopheramines. Tocopheramines and their short-chain analogues are current targets in medicinal chemistry and anti-cancer research.
Export Options
About this article
Cite this article as:
Bohmdorfer Stefan, Gille Lars and Rosenau Thomas, Synthesis of the α-Tocopheramine-15N Model Compound 2,2,5,7,8- Pentamethyl-6-chromanylamine-15N, Letters in Organic Chemistry 2010; 7 (4) . https://dx.doi.org/10.2174/157017810791130612
DOI https://dx.doi.org/10.2174/157017810791130612 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers