Synthesis and In Vitro Evaluation of New Tacrine Derivates-Bis-Alkylene Linked 7-MEOTA

Title: Synthesis and In Vitro Evaluation of New Tacrine Derivates-Bis-Alkylene Linked 7-MEOTA

Volume: 7 Issue: 4

Author(s): Jan Korabecny, Ondrej Holas, Kamil Musilek, Miroslav Pohanka, Veronika Opletalova, Vlastimil Dohnal and Kamil Kuca

Affiliation:

Keywords: Acetylcholinesterase, butyrylcholinesterase, Alzheimer's disease, tacrine, inhibition selectivity

Abstract: Formerly, 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA) was investigated as promising tacrine analogue beneficial for its low toxicity compared to tacrine. In this study, novel 7-MEOTA derivatives were synthesized — namely - 9,9-di-(alkane-1,ω-diyldiimino)-di-(7-methoxy-1,2,3,4-tetrahydroacridine) was prepared from the corresponding diiodoalkanes. The novel compounds exhibit anticholinesterase (acetylcholinesterase and butyrylcholinesterase) activity in vitro. The synthesis and in vitro data are summarized in this article.

Cite this article as:

Korabecny Jan, Holas Ondrej, Musilek Kamil, Pohanka Miroslav, Opletalova Veronika, Dohnal Vlastimil and Kuca Kamil, Synthesis and In Vitro Evaluation of New Tacrine Derivates-Bis-Alkylene Linked 7-MEOTA, Letters in Organic Chemistry 2010; 7 (4) . https://dx.doi.org/10.2174/157017810791130540