Monitoring the Pharmacokinetics of Pyridinium Aldoximes in the Body

H.      Kalasz; J.      Furesz; K.      Tekes

doi:10.2174/138955709788167565

Abstract

A huge number of organophosphate poisonings occurring in agriculture, and a constant threat of misapplication of organophosphates as warfare agents require antidotes that efficiently improve the health-condition of intoxicated subjects. Pyridinium aldoximes are medically used to reactivate the cholinesterase enzymes inhibited by organophosphates. This paper outlines pharmacokinetics, metabolic disposition and blood-brain-barrier penetration of pyridinium aldoximes into the human and animal body, and the methods of their pharmacological analysis.

Keywords: Pyridinium aldoximes, pralidoxime, K-27, K-48, K-203

« Previous Next »