EGF Receptor as a Drug Target in Arterial Hypertension

Title: EGF Receptor as a Drug Target in Arterial Hypertension

Volume: 9 Issue: 5

Author(s): J. Beltowski and E. Lowicka

Affiliation:

Keywords: Epidermal growth factor receptor, arterial hypertension, receptor transactivation, extracellular signal-regulated kinases, receptor tyrosine kinase inhibitors, leptin, metabolic syndrome

Abstract: Drugs which inhibit epidermal growth factor receptor (EGFR) are used in the treatment of cancers. EGFR may contribute to the development of hypertension by regulating vascular tone and renal Na+ handling. Synthetic EGFR inhibitors reduce blood pressure in some experimental models of hypertension suggesting that this receptor is a novel target for antihypertensive therapy.

Cite this article as:

Beltowski J. and Lowicka E., EGF Receptor as a Drug Target in Arterial Hypertension, Mini-Reviews in Medicinal Chemistry 2009; 9 (5) . https://dx.doi.org/10.2174/138955709788167619