Design and Synthesis of Substrates for Model Ribosomal Reactions

Title: Design and Synthesis of Substrates for Model Ribosomal Reactions

Volume: 16 Issue: 4

Author(s): Stanislav G. Bayryamov, Nikolay G. Vassilev, Miroslav A. Rangelov, Aneta P. Mladjova and Dimiter D. Petkov

Affiliation:

Keywords: Design, peptide synthesis, nucleoside synthesis, ribosome catalysis

Abstract: 2/3-O-[Bz(NO2)-Orn(Boc)]-5-O-Piv-Ado (1) and its deoxy analog: 3-O-[Bz(NO2)-Orn(Boc)]-5-O-Piv-2- dAdo (2) were designed and synthesized as substrates for the model ribosome reaction we used to demonstrate the crucial role of A76 2-OH of peptidyl-tRNA in the rate acceleration of peptide bond formation during protein biosynthesis.

Cite this article as:

Bayryamov G. Stanislav, Vassilev G. Nikolay, Rangelov A. Miroslav, Mladjova P. Aneta and Petkov D. Dimiter, Design and Synthesis of Substrates for Model Ribosomal Reactions, Protein & Peptide Letters 2009; 16 (4) . https://dx.doi.org/10.2174/092986609787848009

DOI https://dx.doi.org/10.2174/092986609787848009	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305