Abstract
Two novel double axial chiral guanidines were designed according to the concept of double axial chirality. The practical synthetic procedures from (S)-1,1-binaphthol have been developed. The title compounds were fully characterized by NMR, MS, IR and elemental analysis or HRMS. The two chiral guanidines can be interesting catalysts for asymmetric catalysis and preliminary asymmetric catalytic activity was investigated in Henry reaction and conjugate addition.
Keywords: Guanidine, chiral catalyst, organic base, synthesis
Letters in Organic Chemistry
Title: The Practical Synthesis of Double Axial Chiral Guanidines
Volume: 6 Issue: 3
Author(s): Qun-Sheng Guo and Da-Ming Du
Affiliation:
Keywords: Guanidine, chiral catalyst, organic base, synthesis
Abstract: Two novel double axial chiral guanidines were designed according to the concept of double axial chirality. The practical synthetic procedures from (S)-1,1-binaphthol have been developed. The title compounds were fully characterized by NMR, MS, IR and elemental analysis or HRMS. The two chiral guanidines can be interesting catalysts for asymmetric catalysis and preliminary asymmetric catalytic activity was investigated in Henry reaction and conjugate addition.
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Cite this article as:
Guo Qun-Sheng and Du Da-Ming, The Practical Synthesis of Double Axial Chiral Guanidines, Letters in Organic Chemistry 2009; 6 (3) . https://dx.doi.org/10.2174/157017809787893028
DOI https://dx.doi.org/10.2174/157017809787893028 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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