Design and Synthesis of Thiazolidinedione Derivates as Selective PPARγ Modulators

Title: Design and Synthesis of Thiazolidinedione Derivates as Selective PPARγ Modulators

Volume: 6 Issue: 3

Author(s): Xiangyang Sha, Huibin Zhang, Wenlong Huang, Jinpei Zhou and Yinghong Zhou

Affiliation:

Keywords: Diabetes, PPAR, Synthesis, Thiazolidinedione, Sulfonamino thiourea

Abstract: In this paper we reported the design, synthesis of a series of thiazolidinedione derivates. Their PPARγ activity in vitro was assessed using a reporter gene assay. In this series, it was demonstrated that compound 8f, 8g and 8h with substituted sulfonamino thiourea groups exhibited significant partial agonistic effects on PPARγ.

Cite this article as:

Sha Xiangyang, Zhang Huibin, Huang Wenlong, Zhou Jinpei and Zhou Yinghong, Design and Synthesis of Thiazolidinedione Derivates as Selective PPARγ Modulators, Letters in Drug Design & Discovery 2009; 6 (3) . https://dx.doi.org/10.2174/157018009787847819