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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Design and Synthesis of Thiazolidinedione Derivates as Selective PPARγ Modulators

Author(s): Xiangyang Sha, Huibin Zhang, Wenlong Huang, Jinpei Zhou and Yinghong Zhou

Volume 6, Issue 3, 2009

Page: [224 - 227] Pages: 4

DOI: 10.2174/157018009787847819

Price: $65

Abstract

In this paper we reported the design, synthesis of a series of thiazolidinedione derivates. Their PPARγ activity in vitro was assessed using a reporter gene assay. In this series, it was demonstrated that compound 8f, 8g and 8h with substituted sulfonamino thiourea groups exhibited significant partial agonistic effects on PPARγ.

Keywords: Diabetes, PPAR, Synthesis, Thiazolidinedione, Sulfonamino thiourea


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