Synthesis of Substituted 1H-Pyrrol-2(5H)-ones and 2(5H)-Furanones as Inhibitors of P. aeruginosa Biofilm

Title: Synthesis of Substituted 1H-Pyrrol-2(5H)-ones and 2(5H)-Furanones as Inhibitors of P. aeruginosa Biofilm

Volume: 6 Issue: 2

Author(s): Jia-Liang Guo, Bing-Zhou Li, Wei-Min Chen, Ping-Hua Sun and Yuqiang Wang

Affiliation:

Keywords: Quorum sensing, Biofilm, 2(5H)-Furanones, 1H-Pyrrol-2(5H)-one, Synthesis, P. aeruginosa

Abstract: A series of substituted 1H-pyrrol-2(5H)-ones and three 2(5H)-furanones were designed and chemically synthesized. Their inhibitory activities against P. aeruginosa biofilm formation were investigated by using atomic force microscope (AFM) and scanning electron microscope (SEM) technologies. Brominated 1H-pyrrol-2(5H)-ones were found to significantly inhibit P. aeruginosa biofilm formation.

Cite this article as:

Guo Jia-Liang, Li Bing-Zhou, Chen Wei-Min, Sun Ping-Hua and Wang Yuqiang, Synthesis of Substituted 1H-Pyrrol-2(5H)-ones and 2(5H)-Furanones as Inhibitors of P. aeruginosa Biofilm, Letters in Drug Design & Discovery 2009; 6 (2) . https://dx.doi.org/10.2174/157018009787582642