Abstract
An effective method to prepare racemic α-amino acids was developed. The key reactions involve nitrosation of malonate under basic conditions and reduction of α-hydroxyimino ester derivatives with zinc powder in the presence of acetic anhydride.
Keywords: α-Amino acid, malonate, α-hydroxyimino ester
Letters in Organic Chemistry
Title: A Practical Procedure for Efficient Synthesis of α-Amino Acids
Volume: 6 Issue: 2
Author(s): Shouxin Liu, Debin Ji, Yihua Yang, Xiaoli Zhen, Xia Tian and Jianrong Han
Affiliation:
Keywords: α-Amino acid, malonate, α-hydroxyimino ester
Abstract: An effective method to prepare racemic α-amino acids was developed. The key reactions involve nitrosation of malonate under basic conditions and reduction of α-hydroxyimino ester derivatives with zinc powder in the presence of acetic anhydride.
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Cite this article as:
Liu Shouxin, Ji Debin, Yang Yihua, Zhen Xiaoli, Tian Xia and Han Jianrong, A Practical Procedure for Efficient Synthesis of α-Amino Acids, Letters in Organic Chemistry 2009; 6 (2) . https://dx.doi.org/10.2174/157017809787582744
DOI https://dx.doi.org/10.2174/157017809787582744 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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