Abstract
The aldol reaction of acetate and methyl ketone-based donors with aldehyde acceptors is reviewed. Emphasis is placed on major advances reported in the last 10-15 years. Several methods for inducing chirality at the newly formed stereogenic center are discussed, including popular alternate methods for equivalent syntheses. Different methods for stereospecific synthesis are compared in terms of yield, selectivity, ease of synthesis, and applicability to both small molecule and large macrolide production.
Keywords: DMSO, transition metals, 2-deoxyribose-5-phosphate aldolase (DERA), chiral tridentate titanium, chiral auxiliary, Mannich reactions
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
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