The Role of WNT in Rheumatoid Arthritis and its Therapeutic Implication

Title: The Role of WNT in Rheumatoid Arthritis and its Therapeutic Implication

Volume: 9 Issue: 3

Author(s): Kazushi Imai, Tadashige Chiba, Genta Maeda and Masako Morikawa

Affiliation:

Keywords: WNT, rheumatoid arthritis, FRP, β-catenin, synovium, matrix metalloproteinase

Abstract: Rheumatoid arthritis (RA) is a systematic inflammatory and intractable disease, which progressively affects multiple joints. Recent findings strongly suggest a key role of WNT signaling in the disease initiation and progression. In this review, we discuss the role and possibility of treatment by targeting WNT signaling.

Cite this article as:

Imai Kazushi, Chiba Tadashige, Maeda Genta and Morikawa Masako, The Role of WNT in Rheumatoid Arthritis and its Therapeutic Implication, Mini-Reviews in Medicinal Chemistry 2009; 9 (3) . https://dx.doi.org/10.2174/1389557510909030318