Molecular Modeling Studies of ABC Transporters Involved in Multidrug Resistance

Title: Molecular Modeling Studies of ABC Transporters Involved in Multidrug Resistance

Volume: 9 Issue: 2

Author(s): Aina Westrheim Ravna and Georg Sager

Affiliation:

Keywords: Molecular modeling, P-glycoprotein/ABCB1, MRP4/ABCC4, MRP5/ABCC5, multidrug resistance

Abstract: Multidrug resistance (MDR) is a limitation to cancer chemotherapy, antibiotic treatment and HIV medication. Molecular models of the ABC transporters ABCB1 (P-glycoprotein), ABCC4 (multidrug resistance protein 4 (MRP4)) and ABCC5 (MRP5), which are involved in MDR, may aid in the development of drugs inhibiting anticancer agents efflux.

Cite this article as:

Ravna Westrheim Aina and Sager Georg, Molecular Modeling Studies of ABC Transporters Involved in Multidrug Resistance, Mini-Reviews in Medicinal Chemistry 2009; 9 (2) . https://dx.doi.org/10.2174/138955709787316065