Abstract
Primer Approximation Multiplex PCR (PAMP) is a recently introduced experimental technique for detecting large-scale cancer genome lesions such as inversions and deletions from heterogeneous samples containing a mixture of cancer and normal cells. In this chapter we will first review previous solutions for the problem of selecting sets of PAMP primers that minimize detection failure probability and subsequently review our approach based on integer programming formulations for inversion and deletion detections.
Keywords: Primer approximation multiplex pcr, cancer genomic lesions, efficient algorithms
Current Bioinformatics
Title: A Review of the Primer Approximation Multiplex PCR (PAMP) Technique for Detecting Large Scale Cancer Genomic Lesions
Volume: 4 Issue: 1
Author(s): Kedsuda Apichonbancha, Bhaskar Dasgupta, Jin Jun, Ion Mandoiu and Emma Mendonca
Affiliation:
Keywords: Primer approximation multiplex pcr, cancer genomic lesions, efficient algorithms
Abstract: Primer Approximation Multiplex PCR (PAMP) is a recently introduced experimental technique for detecting large-scale cancer genome lesions such as inversions and deletions from heterogeneous samples containing a mixture of cancer and normal cells. In this chapter we will first review previous solutions for the problem of selecting sets of PAMP primers that minimize detection failure probability and subsequently review our approach based on integer programming formulations for inversion and deletion detections.
Export Options
About this article
Cite this article as:
Apichonbancha Kedsuda, Dasgupta Bhaskar, Jun Jin, Mandoiu Ion and Mendonca Emma, A Review of the Primer Approximation Multiplex PCR (PAMP) Technique for Detecting Large Scale Cancer Genomic Lesions, Current Bioinformatics 2009; 4 (1) . https://dx.doi.org/10.2174/157489309787158161
DOI https://dx.doi.org/10.2174/157489309787158161 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
TNF α Signaling Beholds Thalidomide Saga: A Review of Mechanistic Role of TNF-α Signaling Under Thalidomide
Current Topics in Medicinal Chemistry Shutting Down the Furnace: Preferential Killing of Cancer Cells with Mitochondrial-Targeting Molecules
Current Medicinal Chemistry MicroRNAs in Cancer Gene Therapy: Another Look
Current Cancer Therapy Reviews The Rationale of Targeting Neutrophils with Dapsone during Glioblastoma Treatment
Anti-Cancer Agents in Medicinal Chemistry Na+-H+ Exchanger, pH Regulation and Cancer
Recent Patents on Anti-Cancer Drug Discovery Application of Targeted Therapy to Malignant Gliomas and Response to Treatment
Current Signal Transduction Therapy Liposome-Encapsulated Photosensitizers Against Bacteria
Recent Patents on Anti-Infective Drug Discovery Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds
Current Medicinal Chemistry Drug Delivery Across the Blood-Brain Barrier
Current Nanoscience Better Targeting Melanoma: Options Beyond Surgery and Conventional Chemotherapy
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) The Interaction of Histone Deacetylase Inhibitors and DNA Methyltransferase Inhibitors in the Treatment of Human Cancer Cells
Current Medicinal Chemistry - Anti-Cancer Agents The University of New Mexico Center for Molecular Discovery
Combinatorial Chemistry & High Throughput Screening Chemoradiotherapy of Human Tumors: Novel Approaches from Nanomedicine
Current Pharmaceutical Design Inhibitors of Cyclin Dependent Kinases: Useful Targets for Cancer Treatment
Current Cancer Drug Targets Thrombospondins as Anti-Angiogenic Therapeutic Agents
Current Pharmaceutical Design Multiple Sclerosis, Gut Microbiota and Permeability: Role of Tryptophan Catabolites, Depression and the Driving Down of Local Melatonin
Current Pharmaceutical Design Role of Progesterone in Human Astrocytomas Growth
Current Topics in Medicinal Chemistry Cyclophilin A as a Target of Cisplatin Chemosensitizers
Current Cancer Drug Targets Editorial
Current Radiopharmaceuticals Helper Dependent Adenovirus Vectors: Progress and Future Prospects
Current Gene Therapy