The Anti-Cancer Activity of Noscapine: A Review

Massoud      Mahmoudian; Parvaneh      Rahimi-Moghaddam

doi:10.2174/157489209787002524

Abstract

Noscapine is an isoqiunoline alkaloid found in opium latex. Unlike most other alkaloids obtained from opium latex, noscapine is not sedative and has been used as antitussive drug in various countries. Recently, it has been introduced as an anti-mitotic agent. This drug can be used orally .When the resistance to other anti-cancer drugs such as paclitaxel menifests, noscapine might be effective. Therefore, noscapine and its analogs have great potential as novel anticancer agents.

Keywords: Noscapine, antitussive, anti-cancer, anti-mitotic, apoptosis

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