α-Halogenoacrylic Derivatives of Antitumor Agents

Title: α-Halogenoacrylic Derivatives of Antitumor Agents

Volume: 9 Issue: 1

Author(s): Romeo Romagnoli, Pier Giovanni Baraldi, Olga Cruz-Lopez, Carlota Lopez-Cara and Delia Preti

Affiliation:

Keywords: Antitumor agents, Distamycin A, apoptosis, α-bromoacryloyl, hybrid molecules

Abstract: In this review article we have reported a series of hybrid compounds characterized by the presence of a α- halogenocryloyl alkylating moiety of low chemical reactivity, linked to known antitumor agents or their active moieties. Among them, brostallicin (PNU-166196), was selected for clinical development and is now undergoing Phase II studies in patients with advanced or metastatic soft tissue sarcoma.

Cite this article as:

Romagnoli Romeo, Baraldi Giovanni Pier, Cruz-Lopez Olga, Lopez-Cara Carlota and Preti Delia, α-Halogenoacrylic Derivatives of Antitumor Agents, Mini-Reviews in Medicinal Chemistry 2009; 9 (1) . https://dx.doi.org/10.2174/138955709787001640