One-Pot Rapid and Efficient Synthesis of Gem-Bisallylated Alcohols Mediated by Zinc-Copper Couple under Solvent-free Conditions

Heng      Ren; Yujuan      Wei; Jin-Xian      Wang

doi:10.2174/157017808786857525

Abstract

An efficient and rapid procedure for the conversion of various carboxylic acid derivatives into the corresponding gem-bisallylated compounds under mild reaction conditions has been developed. Zinc-copper couple mediating Barbier- type addition of carboxylic acid derivative was utilized as a key operation to affect the transformation. The procedure is operationally simple, giving good to high product yield.

Keywords: Zinc-copper couple, solvent-free, gem-bisallylated alcohols, allyl bromide

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Letters in Organic Chemistry

Title: One-Pot Rapid and Efficient Synthesis of Gem-Bisallylated Alcohols Mediated by Zinc-Copper Couple under Solvent-free Conditions

Volume: 5 Issue: 8

Author(s): Heng Ren, Yujuan Wei and Jin-Xian Wang

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Keywords: Zinc-copper couple, solvent-free, gem-bisallylated alcohols, allyl bromide

Abstract: An efficient and rapid procedure for the conversion of various carboxylic acid derivatives into the corresponding gem-bisallylated compounds under mild reaction conditions has been developed. Zinc-copper couple mediating Barbier- type addition of carboxylic acid derivative was utilized as a key operation to affect the transformation. The procedure is operationally simple, giving good to high product yield.

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Ren Heng, Wei Yujuan and Wang Jin-Xian, One-Pot Rapid and Efficient Synthesis of Gem-Bisallylated Alcohols Mediated by Zinc-Copper Couple under Solvent-free Conditions, Letters in Organic Chemistry 2008; 5 (8) . https://dx.doi.org/10.2174/157017808786857525