Caldesmon as a Therapeutic Target for Proliferative Vascular Diseases

Title: Caldesmon as a Therapeutic Target for Proliferative Vascular Diseases

Volume: 8 Issue: 12

Author(s): Chi-Ming Hai

Affiliation:

Keywords: Actin, atherosclerosis, caldesmon, calmodulin, restenosis, vascular smooth muscle

Abstract: Caldesmon is a negative regulator of cell proliferation, migration, and metalloproteinase release. Caldesmon function is regulated by multiple kinases, targeting multiple phosphorylation sites. Recently, overexpression of caldesmon has been shown to inhibit neointimal formation after experimental angioplasty, suggesting that caldesmon may be a potential therapeutic target for proliferative vascular diseases.

Cite this article as:

Hai Chi-Ming, Caldesmon as a Therapeutic Target for Proliferative Vascular Diseases, Mini-Reviews in Medicinal Chemistry 2008; 8 (12) . https://dx.doi.org/10.2174/138955708786140981