Abstract
Improved synthesis of 7,11-diarylspiro[5.5]undecane-1,9-dione via double Michael condensation of 1,5- bisaryl-1,4-pentadien-3-one with cyclohexanone was carried out in 51-96% yields for 3-12 h in CH2Cl2-H2O in the presence of phase-transfer catalyst under ultrasound irradiation. In comparison with reported methods, the main advantages of the present procedure are shorter reaction time and higher yields.
Keywords: 7,11-Diarylspiro[5.5]undecane-1, 9-dione, synthesis, ultrasound irradiation, Michael condensation, phase-transfer catalysis
Letters in Organic Chemistry
Title: An Efficient Synthesis of 7,11-diarylspiro[5.5]undecane-1,9-dione by the Michael Condensation Under Ultrasound Irradiation in Aqueous and Organic Two Phase in the Presence of Phase-Transfer Catalyst
Volume: 5 Issue: 7
Author(s): Ji-Tai Li, Xin-Li Zhai, Zhi-Ping Lin and Xiao-Hui Zhang
Affiliation:
Keywords: 7,11-Diarylspiro[5.5]undecane-1, 9-dione, synthesis, ultrasound irradiation, Michael condensation, phase-transfer catalysis
Abstract: Improved synthesis of 7,11-diarylspiro[5.5]undecane-1,9-dione via double Michael condensation of 1,5- bisaryl-1,4-pentadien-3-one with cyclohexanone was carried out in 51-96% yields for 3-12 h in CH2Cl2-H2O in the presence of phase-transfer catalyst under ultrasound irradiation. In comparison with reported methods, the main advantages of the present procedure are shorter reaction time and higher yields.
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Cite this article as:
Li Ji-Tai, Zhai Xin-Li, Lin Zhi-Ping and Zhang Xiao-Hui, An Efficient Synthesis of 7,11-diarylspiro[5.5]undecane-1,9-dione by the Michael Condensation Under Ultrasound Irradiation in Aqueous and Organic Two Phase in the Presence of Phase-Transfer Catalyst, Letters in Organic Chemistry 2008; 5 (7) . https://dx.doi.org/10.2174/157017808785982103
DOI https://dx.doi.org/10.2174/157017808785982103 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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