A Novel Three-Component Reaction of Dibenzylamine and an Aromatic Aldehyde with an Alkyl Isocyanide in the Presence of Silica Gel: An Efficient Route for the One-Pot Synthesis of Sterically Congested 2-(Dibenzylamino)-2-Aryl Acetamide Derivatives

Ebrahim      Ahmadi; Amir   T.   Mahyari; Ali      Ramazani; Mehdi   N.   Haghighi

doi:10.2174/157017808785982158

Abstract

Addition of an isocyanide to an iminium ion intermediate that forms from the reaction between an aromatic aldehyde and dibenzylamine, leads to formation of sterically congested 2-(dibenzylamino)-2-aryl acetamide derivatives in the presence of silica gel powder.

Keywords: Silica gel, multicomponent reaction, isocyanide, aldehyde, secondary amine, iminium ion

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Letters in Organic Chemistry

Title: A Novel Three-Component Reaction of Dibenzylamine and an Aromatic Aldehyde with an Alkyl Isocyanide in the Presence of Silica Gel: An Efficient Route for the One-Pot Synthesis of Sterically Congested 2-(Dibenzylamino)-2-Aryl Acetamide Derivatives

Volume: 5 Issue: 7

Author(s): Ebrahim Ahmadi, Amir T. Mahyari, Ali Ramazani and Mehdi N. Haghighi

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Keywords: Silica gel, multicomponent reaction, isocyanide, aldehyde, secondary amine, iminium ion

Abstract: Addition of an isocyanide to an iminium ion intermediate that forms from the reaction between an aromatic aldehyde and dibenzylamine, leads to formation of sterically congested 2-(dibenzylamino)-2-aryl acetamide derivatives in the presence of silica gel powder.

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Ahmadi Ebrahim, Mahyari T. Amir, Ramazani Ali and Haghighi N. Mehdi, A Novel Three-Component Reaction of Dibenzylamine and an Aromatic Aldehyde with an Alkyl Isocyanide in the Presence of Silica Gel: An Efficient Route for the One-Pot Synthesis of Sterically Congested 2-(Dibenzylamino)-2-Aryl Acetamide Derivatives, Letters in Organic Chemistry 2008; 5 (7) . https://dx.doi.org/10.2174/157017808785982158