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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis of 5-(Carbohydrate-ethynyl)-2-deoxyuridine Derivatives

Author(s): Ruchun Yang, Haixin Ding, Yang Song, Weihong Xiao, Qiang Xiao and Jun Wu

Volume 5, Issue 7, 2008

Page: [518 - 521] Pages: 4

DOI: 10.2174/157017808785982185

Price: $65

Abstract

Sonogashira reaction has been successfully applied to the synthesis of a series of 5-(carbohydrate-ethynyl)-2- deoxyuridines for the first time. The synthetic route is general, high-yielding and compatible with the readily removable protecting group.

Keywords: Sonogashira reaction, 5-iodo-2'-deoxyuridine, 2-propynyl β-D-glycosides, nucleosides derivatives, Palladium catalysis, cross coupling reaction


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