Abstract
Sonogashira reaction has been successfully applied to the synthesis of a series of 5-(carbohydrate-ethynyl)-2- deoxyuridines for the first time. The synthetic route is general, high-yielding and compatible with the readily removable protecting group.
Keywords: Sonogashira reaction, 5-iodo-2'-deoxyuridine, 2-propynyl β-D-glycosides, nucleosides derivatives, Palladium catalysis, cross coupling reaction