Design of Selective G-quadruplex Ligands as Potential Anticancer Agents

Jia-Heng      Tan; Lian-Quan      Gu; Jian-Yong      Wu

doi:10.2174/138955708785909880

Abstract

G-quadruplex structures are promising targets for design of cancer drugs with high selectivity and low toxicity. This review provides an update of the progress made over the last few years in the design of selective G-quadruplex ligands, and a comprehensive summary of the major design strategies and structural characteristics.

Keywords: G-quadruplex, G-quartet, ligands, substituted derivatives, affinity and selectivity, DNA interactions, telomerase inhibition

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Mini-Reviews in Medicinal Chemistry

Title: Design of Selective G-quadruplex Ligands as Potential Anticancer Agents

Volume: 8 Issue: 11

Author(s): Jia-Heng Tan, Lian-Quan Gu and Jian-Yong Wu

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Keywords: G-quadruplex, G-quartet, ligands, substituted derivatives, affinity and selectivity, DNA interactions, telomerase inhibition

Abstract: G-quadruplex structures are promising targets for design of cancer drugs with high selectivity and low toxicity. This review provides an update of the progress made over the last few years in the design of selective G-quadruplex ligands, and a comprehensive summary of the major design strategies and structural characteristics.

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Tan Jia-Heng, Gu Lian-Quan and Wu Jian-Yong, Design of Selective G-quadruplex Ligands as Potential Anticancer Agents, Mini-Reviews in Medicinal Chemistry 2008; 8 (11) . https://dx.doi.org/10.2174/138955708785909880