Urease and α-Chymotrypsin Inhibitory Effects of Selected Urea Derivatives

Title: Urease and α-Chymotrypsin Inhibitory Effects of Selected Urea Derivatives

Volume: 5 Issue: 6

Author(s): Shahnaz Perveen, Khalid Mohammed Khan, Muhammad Arif Lodhi, Muhammad Iqbal Choudhary, Atta-ur-Rahman and Wolfgang Voelter

Affiliation:

Keywords: Urease, α-chymotrypsin, Urea derivatives

Abstract: A number of urea derivatives were synthesized and screened for their urease and α-chymotrypsin inhibition effects, whereby one of the compounds, N-4-nitrophenyl-N’-4’-nitrophenylurea (3), showed strong urease inhibition (IC50 = 1.25μM). We found that the same compound is also an efficient α-chymotrypsin inhibitor having an IC50 value of 3.15μM.

Cite this article as:

Perveen Shahnaz, Khan Mohammed Khalid, Lodhi Arif Muhammad, Choudhary Iqbal Muhammad, Atta-ur-Rahman and Voelter Wolfgang, Urease and α-Chymotrypsin Inhibitory Effects of Selected Urea Derivatives, Letters in Drug Design & Discovery 2008; 5 (6) . https://dx.doi.org/10.2174/157018008785777315