New Synthetic Chalcones: Cytotoxic Mannich Bases of 6-(4-Chlorocinnamoyl)-2(3H)-benzoxazolone

O.      Petrov; Y.      Ivanova; G.      Momekov; V.      Kalcheva

doi:10.2174/157018008785777342

Abstract

A number of Mannich bases were synthesized by a reaction between 6-(4-chlorocinnamoyl)-2(3H)-benzoxazolone, formaldehyde and secondary amines. The structures of the compounds were confirmed by elemental analysis, IR and 1H-NMR spectra. The tested compounds exhibited concentration-dependent cytotoxic effects at low micromolar concentrations with IC50 values ranging between 1.4 and 30.9 μM.

Keywords: Chalcone, 2(3H)-Benzoxazolone, Mannich base, Cytotoxicity

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Letters in Drug Design & Discovery

Title: New Synthetic Chalcones: Cytotoxic Mannich Bases of 6-(4-Chlorocinnamoyl)-2(3H)-benzoxazolone

Volume: 5 Issue: 6

Author(s): O. Petrov, Y. Ivanova, G. Momekov and V. Kalcheva

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Keywords: Chalcone, 2(3H)-Benzoxazolone, Mannich base, Cytotoxicity

Abstract: A number of Mannich bases were synthesized by a reaction between 6-(4-chlorocinnamoyl)-2(3H)-benzoxazolone, formaldehyde and secondary amines. The structures of the compounds were confirmed by elemental analysis, IR and 1H-NMR spectra. The tested compounds exhibited concentration-dependent cytotoxic effects at low micromolar concentrations with IC50 values ranging between 1.4 and 30.9 μM.

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Petrov O., Ivanova Y., Momekov G. and Kalcheva V., New Synthetic Chalcones: Cytotoxic Mannich Bases of 6-(4-Chlorocinnamoyl)-2(3H)-benzoxazolone, Letters in Drug Design & Discovery 2008; 5 (6) . https://dx.doi.org/10.2174/157018008785777342