Fluorescent Agonists and Antagonists for Vasopressin/Oxytocin G Protein-Coupled Receptors: Usefulness in Ligand Screening Assays and Receptor Studies

Title: Fluorescent Agonists and Antagonists for Vasopressin/Oxytocin G Protein-Coupled Receptors: Usefulness in Ligand Screening Assays and Receptor Studies

Volume: 8 Issue: 10

Author(s): B. Mouillac, M. Manning and T. Durroux

Affiliation:

Keywords: Arginine-vasopressin, oxytocin, G protein-coupled receptor, structure-activity relationships, fluorescent peptide, fluorescence resonance energy transfer, fluorescence polarization, high-throughput screening assays

Abstract: Different series of fluorescent agonists and antagonists have been developed and characterized for argininevasopressin and oxytocin G protein-coupled receptors. Both cyclic and linear peptide analogs of the neurohypophysial hormones are useful tools for investigating receptor localization and trafficking, analysing receptor structural organization, and developing new receptor-selective high-throughput ligand screening assays.

Cite this article as:

Mouillac B., Manning M. and Durroux T., Fluorescent Agonists and Antagonists for Vasopressin/Oxytocin G Protein-Coupled Receptors: Usefulness in Ligand Screening Assays and Receptor Studies, Mini-Reviews in Medicinal Chemistry 2008; 8 (10) . https://dx.doi.org/10.2174/138955708785740607