A New Family of Small (4kDa) Neurotoxins from the Venoms of Spiders of the Genus Phoneutria

Title: A New Family of Small (4kDa) Neurotoxins from the Venoms of Spiders of the Genus Phoneutria

Volume: 15 Issue: 7

Author(s): A. D. Lucio, F. V. Campos, M. Richardson, M. N. Cordeiro, M. S.C. Mazzoni, M. E. de Lima, A. M.C. Pimenta, M. P. Bemquerer, S. G. Figueiredo, P. C. Gomes and P. S.L. Beirao

Affiliation:

Keywords: Spider toxin, neurotoxin, Phoneutria, amino acid sequences, L-type Ca 2+ channels, molecular modeling

Abstract: A family of 4kDa neurotoxic peptides was purified from venoms of Phoneutria spiders. All have six cysteine residues, and low similarity with other neurotoxins. Three toxins caused moderate inhibition of L-type Ca2+ channels. The structure of toxin PRTx27C3 was modeled and compared with toxin ADO1. The importance of four residues is suggested.

Cite this article as:

Lucio D. A., Campos V. F., Richardson M., Cordeiro N. M., Mazzoni S.C. M., de Lima E. M., Pimenta M.C. A., Bemquerer P. M., Figueiredo G. S., Gomes C. P. and Beirao S.L. P., A New Family of Small (4kDa) Neurotoxins from the Venoms of Spiders of the Genus Phoneutria, Protein & Peptide Letters 2008; 15 (7) . https://dx.doi.org/10.2174/092986608785133708

DOI https://dx.doi.org/10.2174/092986608785133708	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305