Abstract
This review covers some of the contributions of the authors to the peptidomimetic field. These contributions explore the potential of amino acid-derived α-amino nitriles for generating molecular diversity. Cyanomethyleneamino pseudopeptide analogues of several bioactive peptides and α-quaternary amino nitriles were obtained via a modified three component Strecker synthesis. Taking advantage of the reactivity of the cyano group and the diverse functionality of amino acid derivatives, cyanomethyleneamino pseudopeptides were transformed into carbamoylmethyleneamino and branched pseudopeptides or privileged heterocyclic scaffolds, such as: piperazine, pyrazino[1,2-c]pyrimidine, 1,4- benzodiazepine, and novel indole derivatives, including some spirocyclic compounds.
Keywords: Molecular diversity, diversity oriented synthesis, peptidomimetics, α-Amino nitriles, pseudopeptides, privileged scaffolds
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
3