Abstract
Apoptosis is a programmed cell death process, critical for normal cellular development and tissue homeostasis. B-cell lymphocyte/leukemia 2 (Bcl-2) family proteins are important regulators of apoptosis. Numerous studies have demonstrated that over-expressing anti-apoptotic Bcl-2 proteins is one mechanism for cancer cells to acquire resistance against cancer chemotherapies, suggesting antagonizing these proteins would be a potential approach to overcoming such drug resistance. This review briefly discusses the principle and the recent advances in the development of such antagonists, with some highlights about several promising antagonists.
Keywords: Bcl-2 antagonists, drug resistance, apoptosis, cancer
Mini-Reviews in Organic Chemistry
Title: Antagonists Against Anti-Apoptotic Bcl-2 Family Proteins for Cancer Treatment.
Volume: 5 Issue: 3
Author(s): Jignesh M. Doshi and Chengguo Xing
Affiliation:
Keywords: Bcl-2 antagonists, drug resistance, apoptosis, cancer
Abstract: Apoptosis is a programmed cell death process, critical for normal cellular development and tissue homeostasis. B-cell lymphocyte/leukemia 2 (Bcl-2) family proteins are important regulators of apoptosis. Numerous studies have demonstrated that over-expressing anti-apoptotic Bcl-2 proteins is one mechanism for cancer cells to acquire resistance against cancer chemotherapies, suggesting antagonizing these proteins would be a potential approach to overcoming such drug resistance. This review briefly discusses the principle and the recent advances in the development of such antagonists, with some highlights about several promising antagonists.
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Cite this article as:
Doshi M. Jignesh and Xing Chengguo, Antagonists Against Anti-Apoptotic Bcl-2 Family Proteins for Cancer Treatment., Mini-Reviews in Organic Chemistry 2008; 5 (3) . https://dx.doi.org/10.2174/157019308785161639
DOI https://dx.doi.org/10.2174/157019308785161639 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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