Synthesis, Characterization, and Antimalarial Activity of Novel Schiff-Base-Phenol and Naphthalene-Amine Ligands

Title: Synthesis, Characterization, and Antimalarial Activity of Novel Schiff-Base-Phenol and Naphthalene-Amine Ligands

Volume: 4 Issue: 4

Author(s): Scott E. Harpstrite, Silvia D. Collins, Ana Oksman, Daniel E. Goldberg and Vijay Sharma

Affiliation:

Keywords: Naphthalene-amine, Schiff-base phenol, antimalarials, chloroquine-resistance, P. falciparum

Abstract: Emergence of chloroquine (CQ) resistant Plasmodium falciparum strains necessitates discovery of inexpensive antimalarial drugs capable of targeting CQ-resistant strains. Towards this objective, herein we have synthesized and characterized naphthalene-Schiff bases or naphthalene-amine phenols. Among these compounds, 7 demonstrated a significant bioactivity with a half-maximal inhibitory concentration (IC50) of 1.7 μM against CQ-resistant Dd2 strains.

Cite this article as:

Harpstrite E. Scott, Collins D. Silvia, Oksman Ana, Goldberg E. Daniel and Sharma Vijay, Synthesis, Characterization, and Antimalarial Activity of Novel Schiff-Base-Phenol and Naphthalene-Amine Ligands, Medicinal Chemistry 2008; 4 (4) . https://dx.doi.org/10.2174/157340608784872280