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Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

New Lanthanide Complexes with Antioxidant Activity

Author(s): Irena Kostova, Maria Traykova and Vinod K. Rastogi

Volume 4, Issue 4, 2008

Page: [371 - 378] Pages: 8

DOI: 10.2174/157340608784872181

Price: $65

Abstract

The cerium (III), lanthanum (III) and neodymium (III) complexes of 5-aminoorotic acid were synthesized and their structures were determined by means of theoretical study, spectral and physicochemical analysis. Significant differences in the spectra of the complexes were observed as compared to the spectra of the ligand. The ligand and the complexes were tested for the antioxidant activity. The results obtained indicate that the tested compounds exerted a considerable antioxidant effect upon the evaluated radicals formation in the blood plasma of Wistar rat.

Keywords: Lanthanide (III) complexes, 5-Aminoorotic acid, antioxidant activity


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