Electrophilic Substitution Reaction of Indole: Part XXII-Synthesis of a Novel Spiro Heterocyclic System

Anupam      Nayak; Asima      Chatterjee; Julie      Banerji; Munmun      Saha; Sukumar      Manna; Sanchayita      Kanrar; Tomoyasu      Hirose

doi:10.2174/157017808784872070

Abstract

The reaction of indole with acetone in the presence of mineral/Lewis acid continues to be a fascinating area for investigation since 1913, specially due to the instability of the indolyl carbinol being generated in situ. We report here the synthesis of a novel spiro heterocyclic system obtained during the study of this reaction using BF3.Et2O.

Keywords: Indole, acetone, spiro system, X-ray crystallography

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Letters in Organic Chemistry

Title: Electrophilic Substitution Reaction of Indole: Part XXII-Synthesis of a Novel Spiro Heterocyclic System

Volume: 5 Issue: 5

Author(s): Anupam Nayak, Asima Chatterjee, Julie Banerji, Munmun Saha, Sukumar Manna, Sanchayita Kanrar and Tomoyasu Hirose

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Keywords: Indole, acetone, spiro system, X-ray crystallography

Abstract: The reaction of indole with acetone in the presence of mineral/Lewis acid continues to be a fascinating area for investigation since 1913, specially due to the instability of the indolyl carbinol being generated in situ. We report here the synthesis of a novel spiro heterocyclic system obtained during the study of this reaction using BF3.Et2O.

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Nayak Anupam, Chatterjee Asima, Banerji Julie, Saha Munmun, Manna Sukumar, Kanrar Sanchayita and Hirose Tomoyasu, Electrophilic Substitution Reaction of Indole: Part XXII-Synthesis of a Novel Spiro Heterocyclic System, Letters in Organic Chemistry 2008; 5 (5) . https://dx.doi.org/10.2174/157017808784872070