The Facile and Efficient Three-Component One-Pot Mannich-Type Reaction of Indoles Catalyzed by In(OTf)3 Under Microwave Irradiations

Dipak      Prajapati; Sunil      Gadhwal; Rupam      Sarma

doi:10.2174/157017808784872133

Abstract

Indium triflate catalysed the three-component one-pot reaction of indole 1 with a heteroimine generated in situ under microwave irradiations and afforded predominately secondary indolyl amines 4 in excellent yields as well as bisindolyl methane 5 in poor yields. The catalyst indium triflate can be recovered after the reaction and reused in the subsequent experiments.

Keywords: Indoles, indium triflate, microwave irradiations, multicomponent reactions, Mannich-type reactions, bisindolyl methane

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Letters in Organic Chemistry

Title: The Facile and Efficient Three-Component One-Pot Mannich-Type Reaction of Indoles Catalyzed by In(OTf)3 Under Microwave Irradiations

Volume: 5 Issue: 5

Author(s): Dipak Prajapati, Sunil Gadhwal and Rupam Sarma

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Keywords: Indoles, indium triflate, microwave irradiations, multicomponent reactions, Mannich-type reactions, bisindolyl methane

Abstract: Indium triflate catalysed the three-component one-pot reaction of indole 1 with a heteroimine generated in situ under microwave irradiations and afforded predominately secondary indolyl amines 4 in excellent yields as well as bisindolyl methane 5 in poor yields. The catalyst indium triflate can be recovered after the reaction and reused in the subsequent experiments.

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Prajapati Dipak, Gadhwal Sunil and Sarma Rupam, The Facile and Efficient Three-Component One-Pot Mannich-Type Reaction of Indoles Catalyzed by In(OTf)3 Under Microwave Irradiations, Letters in Organic Chemistry 2008; 5 (5) . https://dx.doi.org/10.2174/157017808784872133