Iodine/EtOH: A Novel and Versatile Catalyst for the Synthesis of β-Amino Ketones via Three Component Reaction

Jhillu   S.   Yadav; Basi   V.S.   Reddy; Kattela   S.   Shankar; Kokku      Premalatha; Tallapally      Swamy

doi:10.2174/157017808784872115

Abstract

A variety of β-amino ketones are readily prepared in high yields and with good to excellent anti selectivity under extremely mild conditions by means of three component coupling of aromatic aldehydes, aryl amines and ketones using 10 mol% of molecular iodine in ethanol. The use of readily available iodine makes this process quite simple, more convenient and cost-effective.

Keywords: Iodine catalysis, β-amino carbonyls, three component reaction

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Letters in Organic Chemistry

Title: Iodine/EtOH: A Novel and Versatile Catalyst for the Synthesis of β-Amino Ketones via Three Component Reaction

Volume: 5 Issue: 5

Author(s): Jhillu S. Yadav, Basi V.S. Reddy, Kattela S. Shankar, Kokku Premalatha and Tallapally Swamy

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Keywords: Iodine catalysis, β-amino carbonyls, three component reaction

Abstract: A variety of β-amino ketones are readily prepared in high yields and with good to excellent anti selectivity under extremely mild conditions by means of three component coupling of aromatic aldehydes, aryl amines and ketones using 10 mol% of molecular iodine in ethanol. The use of readily available iodine makes this process quite simple, more convenient and cost-effective.

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Yadav S. Jhillu, Reddy V.S. Basi, Shankar S. Kattela, Premalatha Kokku and Swamy Tallapally, Iodine/EtOH: A Novel and Versatile Catalyst for the Synthesis of β-Amino Ketones via Three Component Reaction, Letters in Organic Chemistry 2008; 5 (5) . https://dx.doi.org/10.2174/157017808784872115