Palladium-Catalyzed Asymmetric Allylic Substitution Using Phosphoramidite Ligands Bearing 1,1-Binaphthyl Skeleton

Yongguang      Gao; Xinsheng      Li; Weiyi      Chen; Dongcheng      Xu

doi:10.2174/157017808784872179

Abstract

A series of chiral phosphoramidite ligands with 1,1-binaphthyl skeleton have been used in palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenylallyl acetate, which afford substituted products in excellent yields (up to 100 %) and good enantiometric excesses (up to 83 % ee).

Keywords: Asymmetric synthesis, allylic alkylation, phosphoramidite, palladium, catalyst, complex

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Letters in Organic Chemistry

Title: Palladium-Catalyzed Asymmetric Allylic Substitution Using Phosphoramidite Ligands Bearing 1,1-Binaphthyl Skeleton

Volume: 5 Issue: 5

Author(s): Yongguang Gao, Xinsheng Li, Weiyi Chen and Dongcheng Xu

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Keywords: Asymmetric synthesis, allylic alkylation, phosphoramidite, palladium, catalyst, complex

Abstract: A series of chiral phosphoramidite ligands with 1,1-binaphthyl skeleton have been used in palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenylallyl acetate, which afford substituted products in excellent yields (up to 100 %) and good enantiometric excesses (up to 83 % ee).

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Gao Yongguang, Li Xinsheng, Chen Weiyi and Xu Dongcheng, Palladium-Catalyzed Asymmetric Allylic Substitution Using Phosphoramidite Ligands Bearing 1,1-Binaphthyl Skeleton, Letters in Organic Chemistry 2008; 5 (5) . https://dx.doi.org/10.2174/157017808784872179