Design and Synthesis of Novel Thioether-linked Carbapenem-Oxazolidinone Hybrids as Potential Antimicrobial Agents

Jianwei      Wang; Juan      Huang; Yong      Wu; Li      Hai; Guangming      Wang

doi:10.2174/157017808784872043

Abstract

Discovery of novel antimicrobial agents effective against infections caused by drug-resistant pathogens is an important objective in drug research field. In order to find new structural classes of antibiotics, a series of novel thioetherlinked carbapenem-oxazolidinone hybrids were synthesized. The structures of the hybrids and intermediates were confirmed by 1H NMR, IR, MS and elemental analysis.

Keywords: Carbapenem, oxazolidinone, antimicrobial agent, hybrid, drug-resistant, synthesis

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Letters in Organic Chemistry

Title: Design and Synthesis of Novel Thioether-linked Carbapenem-Oxazolidinone Hybrids as Potential Antimicrobial Agents

Volume: 5 Issue: 5

Author(s): Jianwei Wang, Juan Huang, Yong Wu, Li Hai and Guangming Wang

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Keywords: Carbapenem, oxazolidinone, antimicrobial agent, hybrid, drug-resistant, synthesis

Abstract: Discovery of novel antimicrobial agents effective against infections caused by drug-resistant pathogens is an important objective in drug research field. In order to find new structural classes of antibiotics, a series of novel thioetherlinked carbapenem-oxazolidinone hybrids were synthesized. The structures of the hybrids and intermediates were confirmed by 1H NMR, IR, MS and elemental analysis.

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Wang Jianwei, Huang Juan, Wu Yong, Hai Li and Wang Guangming, Design and Synthesis of Novel Thioether-linked Carbapenem-Oxazolidinone Hybrids as Potential Antimicrobial Agents, Letters in Organic Chemistry 2008; 5 (5) . https://dx.doi.org/10.2174/157017808784872043