Abstract
The basic and catalytic properties of hydrotalcites, supported fluorides and mixed oxides are reviewed, with a special emphasis on C-C bond forming reactions. Relatively strong basicity can be induced on hydrotalcites by calcination followed by rehydration. In that case the shift from Lewis to Bronsted basicity has strong influence on the catalytic properties. The basicity is further enhanced by introduction of t-butoxide or fluoride anions in place of hydroxyls, while chloride anions inhibit activity. Excellent yields have been reported, by fine-tuning of basic sites of the hydrotaclites, supported fluorides and mixed oxides as exemplified in aldol, Henry, Knoevenagel, Michael, trans-esterification Wadsworth- Emmons and N-oxidation reactions. In many cases the catalysts can be recycled.
Keywords: tert-butyl hydroperoxide, Henry reaction, aliphatic aldehydes, Isomerization, Wadsworth-Emmons reactions, hydrotalcite (HDT)
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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