Hypotensive Natural Products: Current Status

Title: Hypotensive Natural Products: Current Status

Volume: 8 Issue: 8

Author(s): Monica Rosa Loizzo, Rosa Tundis, Federica Menichini, Giancarlo Antonio Statti and Francesco Menichini

Affiliation:

Keywords: Hypertension, alkaloids, terpenoids, poliphenols, miscellaneous

Abstract: Hypertension is a common and progressive disorder that possesses a major risk for cardiovascular and renal disease. Recent data have revealed that the global burden of hypertension is an important and increasing public health problem worldwide and that the level of awareness, treatment and control of hypertension varies considerably among countries. Hypertension is often called a ‘silent killer’ because persons with this pathological condition can be asymptomatic for years and then have a fatal heart attack or stroke. The field of naturally occurring antihypertensive agent is a research area rapidly expanding due to the high potential of such molecules as new antihypertensive drugs. Recently, a great number of plant-derived substances have been evaluated as possible antihypertensive agents through different mechanisms of action such as alkaloids, flavonoids and terpenoids. In this mini-review we will discuss the medicinal chemistry of these compounds.

Cite this article as:

Loizzo Rosa Monica, Tundis Rosa, Menichini Federica, Statti Antonio Giancarlo and Menichini Francesco, Hypotensive Natural Products: Current Status, Mini-Reviews in Medicinal Chemistry 2008; 8 (8) . https://dx.doi.org/10.2174/138955708784912157