Prediction of Binding Motifs in Hepatitis C Virus NS5A and Human Proteins

Guang-Zheng      Zhang; Kyungsook      Han

doi:10.2174/092986608784567500

Abstract

From the extensive analysis, we identified three highly conserved sequence segments in HCV NS5A proteins and one binding motif in human proteins. The binding motif of human proteins often forms a full helix or an extended strand-loop structure, and is in good agreement with the experimental findings of previous studies.

Keywords: Binding motif, protein-protein interaction, hepatitis C virus, human protein, binding site

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Protein & Peptide Letters

Title: Prediction of Binding Motifs in Hepatitis C Virus NS5A and Human Proteins

Volume: 15 Issue: 5

Author(s): Guang-Zheng Zhang and Kyungsook Han

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Keywords: Binding motif, protein-protein interaction, hepatitis C virus, human protein, binding site

Abstract: From the extensive analysis, we identified three highly conserved sequence segments in HCV NS5A proteins and one binding motif in human proteins. The binding motif of human proteins often forms a full helix or an extended strand-loop structure, and is in good agreement with the experimental findings of previous studies.

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Zhang Guang-Zheng and Han Kyungsook, Prediction of Binding Motifs in Hepatitis C Virus NS5A and Human Proteins, Protein & Peptide Letters 2008; 15 (5) . https://dx.doi.org/10.2174/092986608784567500