Recent Developments in the Discovery of Selective Glucocorticoid Receptor Modulators (SGRMs)

Title: Recent Developments in the Discovery of Selective Glucocorticoid Receptor Modulators (SGRMs)

Volume: 8 Issue: 9

Author(s): Andrew R. Hudson, Steven L. Roach and Robert I. Higuchi

Affiliation:

Keywords: SGRM, glucocorticoid, nonsteroidal, modulator, transactivation, transrepression, dissociated, inflammation, multiple myeloma

Abstract: Steroidal glucocorticoids are widely prescribed for the treatment of a variety of inflammatory and autoimmune diseases. Although they are effective, the side-effects associated with chronic glucocorticoid treatment, such as osteoporosis and hyperglycemia, can severely limit their long-term use. Hence, there is a need to develop new effective anti-inflammatory agents for systemic use which are dissociated from their unwanted side effects.

Cite this article as:

Hudson R. Andrew, Roach L. Steven and Higuchi I. Robert, Recent Developments in the Discovery of Selective Glucocorticoid Receptor Modulators (SGRMs), Current Topics in Medicinal Chemistry 2008; 8 (9) . https://dx.doi.org/10.2174/156802608784535048