Modulation by Dopaminergic System of Morphine Withdrawal: In Vitro Evidences

A.      Capasso

doi:10.2174/157018008784619906

Abstract

The effects exerted by cocaine, amphetamine and phencyclidine on the acute opiate withdrawal induced by morphine were investigated in vitro. The results of our experiments indicate that cocaine, amphetamine and phencyclidine are able to influence opiate withdrawal in vitro thus confirming an important functional interaction between the dopaminergic system and opioid withdrawal.

Keywords: Dependence, Dopamine, Morphine, Cocaine, Amphetamine, Phencyclidine

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Letters in Drug Design & Discovery

Title: Modulation by Dopaminergic System of Morphine Withdrawal: In Vitro Evidences

Volume: 5 Issue: 4

Author(s): A. Capasso

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Keywords: Dependence, Dopamine, Morphine, Cocaine, Amphetamine, Phencyclidine

Abstract: The effects exerted by cocaine, amphetamine and phencyclidine on the acute opiate withdrawal induced by morphine were investigated in vitro. The results of our experiments indicate that cocaine, amphetamine and phencyclidine are able to influence opiate withdrawal in vitro thus confirming an important functional interaction between the dopaminergic system and opioid withdrawal.

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Capasso A., Modulation by Dopaminergic System of Morphine Withdrawal: In Vitro Evidences, Letters in Drug Design & Discovery 2008; 5 (4) . https://dx.doi.org/10.2174/157018008784619906