Building Quantitative Relationship Between Changed Sequence and Changed Oxygen Affinity in Human Hemoglobin β-Chain

Title: Building Quantitative Relationship Between Changed Sequence and Changed Oxygen Affinity in Human Hemoglobin β-Chain

Volume: 15 Issue: 4

Author(s): Guang Wu and Shaomin Yan

Affiliation:

Keywords: Amino acid, Bayes' law, cross-impact analysis, distribution probability, hemoglobin, oxygen affinity

Abstract: 244 point mutations have been recorded in human hemoglobin β-chain, of which some change the oxygen affinity of human hemoglobin β-chain. We use the amino-acid distribution probability to quantify these mutations, and use the cross-impact analysis with Bayes law to determine the probability that changes the oxygen affinity of human hemoglobin β-chain under mutations.

Cite this article as:

Wu Guang and Yan Shaomin, Building Quantitative Relationship Between Changed Sequence and Changed Oxygen Affinity in Human Hemoglobin β-Chain, Protein & Peptide Letters 2008; 15 (4) . https://dx.doi.org/10.2174/092986608784246498

DOI https://dx.doi.org/10.2174/092986608784246498	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305