Synthesis and Biological Evaluation of N-(Alkyl)-2-Thiophen-2-Ylacetamides Series As A New Class of Antitubercular Agents

Title: Synthesis and Biological Evaluation of N-(Alkyl)-2-Thiophen-2-Ylacetamides Series As A New Class of Antitubercular Agents

Volume: 5 Issue: 3

Author(s): Marcus Vinicius Nora de Souza, Marcelle de Lima Ferreira, Thais Cristina Mendonca Nogueira, Raoni Schroeder Borges Goncalves, Monica Amado Peralta, Maria Cristina Silva Lourenco and Felipe Rodrigues Vicente

Affiliation:

Keywords: Tuberculosis, Multidrug-resistance, Thiophene, Thiopheneacetamides, Antimycobacterial activity, Alamar blue assay

Abstract: The present article describes a series of eleven N-(alkyl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in μgmL. . The compounds 3g and 3k exhibited the respective activities of 25 and 50 μg/mL being a new class of compounds against tuberculosis.

Cite this article as:

Nora de Souza Vinicius Marcus, Ferreira de Lima Marcelle, Mendonca Nogueira Cristina Thais, Borges Goncalves Schroeder Raoni, Peralta Amado Monica, Silva Lourenco Cristina Maria and Vicente Rodrigues Felipe, Synthesis and Biological Evaluation of N-(Alkyl)-2-Thiophen-2-Ylacetamides Series As A New Class of Antitubercular Agents, Letters in Drug Design & Discovery 2008; 5 (3) . https://dx.doi.org/10.2174/157018008784083965