A Simple and Efficient One-Pot Synthesis of Spirooxindoles in Water Under Microwave Irradiation Conditions

Song-Lei      Zhu; Shun-Jun      Ji; Kai      Zhao; Yong      Zhang

doi:10.2174/157017808784049489

Abstract

A simple and efficient method for the synthesis of spirooxindoles derivatives by one-pot reactions of isatins, activated methylene reagents and activated carbonyl compounds in water under microwave irradiation was reported. This protocol has the advantages of short reaction time, high yields, easy work-up procedure and environmentally benign characters.

Keywords: Spirooxindoles, three-component synthesis, microwave irradiation, aqueous media

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Letters in Organic Chemistry

Title: A Simple and Efficient One-Pot Synthesis of Spirooxindoles in Water Under Microwave Irradiation Conditions

Volume: 5 Issue: 4

Author(s): Song-Lei Zhu, Shun-Jun Ji, Kai Zhao and Yong Zhang

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Keywords: Spirooxindoles, three-component synthesis, microwave irradiation, aqueous media

Abstract: A simple and efficient method for the synthesis of spirooxindoles derivatives by one-pot reactions of isatins, activated methylene reagents and activated carbonyl compounds in water under microwave irradiation was reported. This protocol has the advantages of short reaction time, high yields, easy work-up procedure and environmentally benign characters.

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Zhu Song-Lei, Ji Shun-Jun, Zhao Kai and Zhang Yong, A Simple and Efficient One-Pot Synthesis of Spirooxindoles in Water Under Microwave Irradiation Conditions, Letters in Organic Chemistry 2008; 5 (4) . https://dx.doi.org/10.2174/157017808784049489