Synthesis and Characterization of Two Novel Stigmasterol-Based Cationic Lipids

Jia      Qian; Zhiping      Le; Fei      Yu; Pinghan      Jiang

doi:10.2174/157017808784049461

Abstract

Two novel stigmasterol-based cationic lipids, Stigmasta-5,22-dien-3-ol,4-[[2- (dimethylamino)ethyl]amino]-4- oxobutanoate,(3β,22E)-(9CI) and stigmasta-5,22-dien- 3-ol,4-[[2-(dimethylamino)ethyl]amino](2E)-4-oxobutenoate, (3β,22E)-(9CI), were synthesized. These compounds were characterized by mass spectrometry (MS), nuclear magnetic resonance (NMR) and fourier transform infrared (FT-IR).

Keywords: Cationic lipids, stigmasterol, synthesis, characterization

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Letters in Organic Chemistry

Title: Synthesis and Characterization of Two Novel Stigmasterol-Based Cationic Lipids

Volume: 5 Issue: 4

Author(s): Jia Qian, Zhiping Le, Fei Yu and Pinghan Jiang

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Keywords: Cationic lipids, stigmasterol, synthesis, characterization

Abstract: Two novel stigmasterol-based cationic lipids, Stigmasta-5,22-dien-3-ol,4-[[2- (dimethylamino)ethyl]amino]-4- oxobutanoate,(3β,22E)-(9CI) and stigmasta-5,22-dien- 3-ol,4-[[2-(dimethylamino)ethyl]amino](2E)-4-oxobutenoate, (3β,22E)-(9CI), were synthesized. These compounds were characterized by mass spectrometry (MS), nuclear magnetic resonance (NMR) and fourier transform infrared (FT-IR).

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Qian Jia, Le Zhiping, Yu Fei and Jiang Pinghan, Synthesis and Characterization of Two Novel Stigmasterol-Based Cationic Lipids, Letters in Organic Chemistry 2008; 5 (4) . https://dx.doi.org/10.2174/157017808784049461