Generic placeholder image

Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

An Improved Synthetic Protocol and Plausible Mechanism in Forming Acetylpyridines from 2,6-Dicarbethoxypyridine

Author(s): Maliha Asma, Sheriff Adewuyi, Xiaofei Kuang, Amin Badshah and Wen-Hua Sun

Volume 5, Issue 4, 2008

Page: [296 - 299] Pages: 4

DOI: 10.2174/157017808784049515

Price: $65

Abstract

2-Carbethoxy-6-acetylpyridine and 2,6-diacetylpyridine were transformed in good yields from the reaction of 2,6-dicarbethoxypyridine and EtOAc in the presence of sodium along with/without an equivalent of ethanol to sodium in toluene. The β-keto esters, the intermediates in the transformation of β-keto carboxylate into acetyl group, were isolated for understanding the plausible mechanism.

Keywords: 2-Carbethoxy-6-acetylpyridine, 2,6-diacetylpyridine, 2,6-dicarbethoxypyridine, Claisen Ester Condensation, anti-Claisen reaction


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy