Synthesis of NH-Aziridines from Vicinal Amino Alcohols Via the Wenker Reaction: Scope and Limitation

Min      Zhu; Libo      Hu; Ning      Chen; Da-Ming      Du; Jiaxi      Xu

doi:10.2174/157017808783955844

Abstract

The Wenker reaction is an efficient and practical method for the synthesis of NH-aziridines from vicinal amino alcohols. However, some limitation in the application has been reported. The scope and limitation of the Wenker reaction were investigated with a series of structurally diverse and representative vicinal amino alcohols.

Keywords: Aziridine, amino alcohol, cyclization, heterocyclic compound, Wenker reaction, synthesis

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Letters in Organic Chemistry

Title: Synthesis of NH-Aziridines from Vicinal Amino Alcohols Via the Wenker Reaction: Scope and Limitation

Volume: 5 Issue: 3

Author(s): Min Zhu, Libo Hu, Ning Chen, Da-Ming Du and Jiaxi Xu

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Keywords: Aziridine, amino alcohol, cyclization, heterocyclic compound, Wenker reaction, synthesis

Abstract: The Wenker reaction is an efficient and practical method for the synthesis of NH-aziridines from vicinal amino alcohols. However, some limitation in the application has been reported. The scope and limitation of the Wenker reaction were investigated with a series of structurally diverse and representative vicinal amino alcohols.

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Zhu Min, Hu Libo, Chen Ning, Du Da-Ming and Xu Jiaxi, Synthesis of NH-Aziridines from Vicinal Amino Alcohols Via the Wenker Reaction: Scope and Limitation, Letters in Organic Chemistry 2008; 5 (3) . https://dx.doi.org/10.2174/157017808783955844