Comparative Antiviral (HIV) Photoactivity of Metalized meso-Tetraphenylsulfonated Porphyrins

Title: Comparative Antiviral (HIV) Photoactivity of Metalized meso-Tetraphenylsulfonated Porphyrins

Volume: 4 Issue: 2

Author(s): Franklin Vargas, Carlos Rivas, Tamara Zoltan, Liliana Padron, Carla Izzo, Veronica Lopez, Lubimar Gomez, Flor Pujol, Hector Rangel, Domingo Garzaro and Rona Fabbro

Affiliation:

Keywords: meso-Tetraphenylsulfonated porphyrins, HIV, metallo porphyrins, photoinactivation, phototherapy, phototoxicity, photosensitizer, antiviral, singlet oxygen.

Abstract: We have carried out the study of the photochemical properties of a series of synthetic mesotetraphenylsulfonated porphyrins (TPPMS4) bonded to several metal ions such as: Cu(II), Zn(II), Pd(II), Mn(II), Fe(III), Ni(II) and Co(II) for the optimization of their clinical applications as antiviral agents against the human immunodeficiency virus (HIV-1) as well as the study of the in vitro antiviral photoinactivation mechanisms with future application in blood sterilization. A selective inhibition has been determined in the viral growth (HIV-1) when this is irradiated in the presence of the complex TPPFeS4 and TPPMnS4 (photosensitizer-mediated Type I reaction) as well as in the 1O2- mediated (Type II reaction) in the presence of TPPPdS4 and TPPZnS4, remaining cellular viability unaltered in each case.

Cite this article as:

Vargas Franklin, Rivas Carlos, Zoltan Tamara, Padron Liliana, Izzo Carla, Lopez Veronica, Gomez Lubimar, Pujol Flor, Rangel Hector, Garzaro Domingo and Fabbro Rona, Comparative Antiviral (HIV) Photoactivity of Metalized meso-Tetraphenylsulfonated Porphyrins, Medicinal Chemistry 2008; 4 (2) . https://dx.doi.org/10.2174/157340608783789167