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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

A Docking Modelling Rationally Predicts Strong Binding of Bisphenol A to Estrogen-Related Receptor γ

Author(s): Takeru Nose and Yasuyuki Shimohigashi

Volume 15, Issue 3, 2008

Page: [290 - 296] Pages: 7

DOI: 10.2174/092986608783744261

Price: $65

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Abstract

A computer-aided docking study was carried out to quickly clarify the binding structure of the ligand-receptor complex between bisphenol A (BPA), a well-known endocrine disruptor, and estrogen-related receptor γ (ERRγ). The resulting complex indicated that BPA binds to the ligand-binding pocket of ERRγ without any disruptions of the activation conformation.

Keywords: Estrogen-related receptor γ, bisphenol A, endocrine disruptors, docking calculation


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