Direct Propargylic Substitution of Hydroxyl Group in Propargylic Alcohols

George   W.   Kabalka; Min-Liang      Yao

doi:10.2174/157017908783497536

Abstract

Nucleophilic substitution reactions involving propargylic alcohols are important because the alkynyl group can be subsequently transformed into a variety of functional groups. This review summarizes recent direct substitution reactions of hydroxyl groups in propargylic alcohols, reactions that are highly desirable due to atom efficiency and environmental concerns.

Keywords: Ruthenium Catalyzed Substitution, propargylamines, aromatic propargylation, alkoxides, regioselectivity

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Current Organic Synthesis

Title: Direct Propargylic Substitution of Hydroxyl Group in Propargylic Alcohols

Volume: 5 Issue: 1

Author(s): George W. Kabalka and Min-Liang Yao

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Keywords: Ruthenium Catalyzed Substitution, propargylamines, aromatic propargylation, alkoxides, regioselectivity

Abstract: Nucleophilic substitution reactions involving propargylic alcohols are important because the alkynyl group can be subsequently transformed into a variety of functional groups. This review summarizes recent direct substitution reactions of hydroxyl groups in propargylic alcohols, reactions that are highly desirable due to atom efficiency and environmental concerns.

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Kabalka W. George and Yao Min-Liang, Direct Propargylic Substitution of Hydroxyl Group in Propargylic Alcohols, Current Organic Synthesis 2008; 5 (1) . https://dx.doi.org/10.2174/157017908783497536