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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

N-Myristoyltransferase: A Novel Target

Author(s): M. P. Toraskar, K. K. Prasad and V. J. Kadam

Volume 8, Issue 2, 2008

Page: [142 - 149] Pages: 8

DOI: 10.2174/138955708783498159

Price: $65

Abstract

Myristoyl-CoA:Protein N-myristoyltranferase (NMT) is a cytosolic monomeric enzyme which catalyses the transfer of a rare fatty acid , myristate from myristoyl-CoA to the N-terminal glycine residue of a variety of eukaryotic and viral proteins. N-myristoyltransferase is a novel target for Anticancer, Antiviral and antifungal agents. Recent Nmyristoyltransferase inhibitors like benzofurans and benzothiazole derivatives show in vivo antifungal activity and are promising selective fungal N-myristoyltransferase inhibitors.

Keywords: N-myristoyltransferase, myristoylation, benzofurans, benzothiazoles, antifungal, Candida albicans, anticancer, antiviral


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